Our laboratory is interested in how rare and de novo mutations in the human genome contribute to patterns of genetic variation and risk for disease in humans. To this end, we are developing novel approaches to gene discovery that are based on advanced technologies for the detection of rare variants, including studies of copy number variation (CNV) and deep whole genome sequencing (WGS). Our goal is to identify genes related to psychiatric disorders and determine how genetic variants impact the function of genes and corresponding cellular pathways.
Chief, Beyster Center for Molecular Genomics of Neuropsychiatric Diseases; Associate Professor of Psychiatry and Cellular & Molecular Medicine
Bioinformatics and Systems Biology
Brief Research Description
Genome informatics, psychiatric genetics, copy number variation (CNV), de novo mutation