Bioinformatics and Systems Biology
Brief Research Description
Gene Regulatory Networks
The laboratory’s research is focused on understanding the fundamental mechanisms controlling gene expression in mammalian cells. In particular, the laboratory is investigating three related problems:
- What are the transcriptional regulatory sequences that control cell-specific gene expression programs in the mammalian genomes?
- How do these sequence elements interact with transcription factors and chromatin binding proteins to regulate gene expression during cellular differentiation?
- How do epigenetic mechanisms (DNA methylation and chromatin modifications) influence the gene regulatory process?