Human-specific transcriptional networks in the brain.

TitleHuman-specific transcriptional networks in the brain.
Publication TypeJournal Article
Year of Publication2012
AuthorsKonopka G, Friedrich T, Davis-Turak J, Winden K, Oldham MC, Gao F, Chen L, Wang G-Z, Luo R, Preuss TM, Geschwind DH
JournalNeuron
Volume75
Issue4
Pagination601-17
Date Published2012 Aug 23
ISSN1097-4199
KeywordsAnimals, Brain, CLOCK Proteins, Evolution, Molecular, Forkhead Transcription Factors, Gene Expression, Gene Expression Profiling, Gene Regulatory Networks, Humans, Macaca, Mental Disorders, Oligonucleotide Array Sequence Analysis, Pan troglodytes, Transcription Factors
Abstract

Understanding human-specific patterns of brain gene expression and regulation can provide key insights into human brain evolution and speciation. Here, we use next-generation sequencing, and Illumina and Affymetrix microarray platforms, to compare the transcriptome of human, chimpanzee, and macaque telencephalon. Our analysis reveals a predominance of genes differentially expressed within human frontal lobe and a striking increase in transcriptional complexity specific to the human lineage in the frontal lobe. In contrast, caudate nucleus gene expression is highly conserved. We also identify gene coexpression signatures related to either neuronal processes or neuropsychiatric diseases, including a human-specific module with CLOCK as its hub gene and another module enriched for neuronal morphological processes and genes coexpressed with FOXP2, a gene important for language evolution. These data demonstrate that transcriptional networks have undergone evolutionary remodeling even within a given brain region, providing a window through which to view the foundation of uniquely human cognitive capacities.

DOI10.1016/j.neuron.2012.05.034
PubMed URLhttp://www.ncbi.nlm.nih.gov/pubmed/22920253?dopt=Abstract
PMCPMC3645834
Alternate JournalNeuron
PubMed ID22920253