Transgenerational epigenetic instability is a source of novel methylation variants.

TitleTransgenerational epigenetic instability is a source of novel methylation variants.
Publication TypeJournal Article
Year of Publication2011
AuthorsSchmitz RJ, Schultz MD, Lewsey MG, O'Malley RC, Urich MA, Libiger O, Schork NJ, Ecker JR
JournalScience
Volume334
Issue6054
Pagination369-73
Date Published2011 Oct 21
ISSN1095-9203
KeywordsAlleles, Arabidopsis, Dinucleoside Phosphates, DNA Methylation, DNA Transposable Elements, DNA, Intergenic, DNA, Plant, Epigenesis, Genetic, Genes, Plant, Genetic Variation, Genome, Plant, Linear Models, Mutation, Polymorphism, Genetic, Promoter Regions, Genetic, Transcription, Genetic
Abstract

Epigenetic information, which may affect an organism's phenotype, can be stored and stably inherited in the form of cytosine DNA methylation. Changes in DNA methylation can produce meiotically stable epialleles that affect transcription and morphology, but the rates of spontaneous gain or loss of DNA methylation are unknown. We examined spontaneously occurring variation in DNA methylation in Arabidopsis thaliana plants propagated by single-seed descent for 30 generations. We identified 114,287 CG single methylation polymorphisms and 2485 CG differentially methylated regions (DMRs), both of which show patterns of divergence compared with the ancestral state. Thus, transgenerational epigenetic variation in DNA methylation may generate new allelic states that alter transcription, providing a mechanism for phenotypic diversity in the absence of genetic mutation.

DOI10.1126/science.1212959
PubMed URLhttp://www.ncbi.nlm.nih.gov/pubmed/21921155?dopt=Abstract
PMCPMC3210014
Alternate JournalScience
PubMed ID21921155