Predictive chromatin signatures in the mammalian genome.

TitlePredictive chromatin signatures in the mammalian genome.
Publication TypeJournal Article
Year of Publication2009
AuthorsHon GC, Hawkins DR, Ren B
JournalHum Mol Genet
Volume18
IssueR2
PaginationR195-201
Date Published2009 Oct 15
ISSN1460-2083
KeywordsAnimals, Chromatin, Enhancer Elements, Genetic, Genome, Humans, Mammals
Abstract

The DNA sequence of an organism is a blueprint of life: it harbors not only the information about proteins and other molecules produced in each cell, but also instructions on when and where such molecules are made. Chromatin, the structure of histone and DNA that has co-evolved with eukaryotic genome, also contains information that indicates the function and activity of the underlying DNA sequences. Such information exists in the form of covalent modifications to the histone proteins that comprise the nucleosome. Thanks to the development of high throughput technologies such as DNA microarrays and next generation DNA sequencing, we have begun to associate the various combinations of chromatin modification patterns with functional sequences in the human genome. Here, we review the rapid progress from descriptive observations of histone modification profiles to highly predictive models enabling use of chromatin signatures to enumerate novel functional sequences in mammalian genomes that have escaped previous detection.

DOI10.1093/hmg/ddp409
PubMed URLhttp://www.ncbi.nlm.nih.gov/pubmed/19808796?dopt=Abstract
PMCPMC2912651
Alternate JournalHum. Mol. Genet.
PubMed ID19808796