Reconstruction of biochemical networks in microorganisms.

TitleReconstruction of biochemical networks in microorganisms.
Publication TypeJournal Article
Year of Publication2009
AuthorsFeist AM, Herrgård MJ, Thiele I, Reed JL, Palsson BØ
JournalNat Rev Microbiol
Volume7
Issue2
Pagination129-43
Date Published2009 Feb
ISSN1740-1534
KeywordsBacteria, Gene Expression Regulation, Bacterial, Genome, Bacterial, Metabolomics
Abstract

Systems analysis of metabolic and growth functions in microbial organisms is rapidly developing and maturing. Such studies are enabled by reconstruction, at the genomic scale, of the biochemical reaction networks that underlie cellular processes. The network reconstruction process is organism specific and is based on an annotated genome sequence, high-throughput network-wide data sets and bibliomic data on the detailed properties of individual network components. Here we describe the process that is currently used to achieve comprehensive network reconstructions and discuss how these reconstructions are curated and validated. This review should aid the growing number of researchers who are carrying out reconstructions for particular target organisms.

DOI10.1038/nrmicro1949
PubMed URLhttp://www.ncbi.nlm.nih.gov/pubmed/19116616?dopt=Abstract
PMCPMC3119670
Alternate JournalNat. Rev. Microbiol.
PubMed ID19116616