EchoLOCATION: an in silico analysis of the subcellular locations of Escherichia coli proteins and comparison with experimentally derived locations.

TitleEchoLOCATION: an in silico analysis of the subcellular locations of Escherichia coli proteins and comparison with experimentally derived locations.
Publication TypeJournal Article
Year of Publication2009
AuthorsHorler RSP, Butcher A, Papangelopoulos N, Ashton PD, Thomas GH
JournalBioinformatics
Volume25
Issue2
Pagination163-6
Date Published2009 Jan 15
ISSN1367-4811
KeywordsAlgorithms, Bacterial Outer Membrane Proteins, Databases, Protein, Escherichia coli, Escherichia coli Proteins, Models, Biological, Periplasm, Proteome, Proteomics
Abstract

SUMMARY: EchoLOCATION is a database that provides a comprehensive analysis of the subcellular locations of Escherichia coli K-12 proteins. Locations are predicted by integrating data from a range of publicly available algorithms combined with extensive curation of experimental literature. The data can be searched in a variety of ways and can generate lists of subcellular proteomes for analysis. Experimental evidence supports the locations of over 500 envelope proteins (periplasm, inner and outer membrane). From analysis of disagreements between in silico predictions and experimental data, we provide an analysis of protein types where subcellular prediction algorithms are currently not accurate.

DOI10.1093/bioinformatics/btn596
PubMed URLhttp://www.ncbi.nlm.nih.gov/pubmed/19015139?dopt=Abstract
Alternate TitleBioinformatics
PubMed ID19015139