Epigenetic control: slow and global, nimble and local.

TitleEpigenetic control: slow and global, nimble and local.
Publication TypeJournal Article
Year of Publication2008
AuthorsCheng CS, Johnson TL, Hoffmann A
JournalGenes Dev
Volume22
Issue9
Pagination1110-4
Date Published2008 May 1
ISSN0890-9369
KeywordsAcetylation, Animals, Embryo, Mammalian, Epigenesis, Genetic, Gene Expression Regulation, Developmental, Histone Deacetylases, Mice, Models, Biological, Mutation, NF-kappa B p50 Subunit, Phosphorylation
Abstract

The regulation of gene expression involves multiple levels of control, from those that are inheritable to those that are highly responsive to environmental changes. In this issue of Genes & Development, Dong and colleagues (pp. 1159-1173) demonstrate that the dynamically controlled immune response transcription factor NF-kappaB may, in fact, have a role in regulating heterochromatin and gene expression at large distances from its actual target sequences and genes.

DOI10.1101/gad.1677008
PubMed URLhttp://www.ncbi.nlm.nih.gov/pubmed/18451102?dopt=Abstract
PMCPMC2732403
Alternate JournalGenes Dev.
PubMed ID18451102