Herpes simplex virus type 2 acquisition during recent HIV infection does not influence plasma HIV levels.

TitleHerpes simplex virus type 2 acquisition during recent HIV infection does not influence plasma HIV levels.
Publication TypeJournal Article
Year of Publication2008
AuthorsCachay ER, Frost SDW, Poon AFY, Looney D, Rostami SM, Pacold ME, Richman DD, Little SJ, Smith DM
JournalJ Acquir Immune Defic Syndr
Volume47
Issue5
Pagination592-6
Date Published2008 Apr 15
ISSN1525-4135
KeywordsAdult, CD4 Lymphocyte Count, Cohort Studies, Herpes Simplex, Herpesvirus 2, Human, HIV, HIV Infections, Humans, Male, Middle Aged, Retrospective Studies, RNA, Viral, Viral Load
Abstract

We assessed the effect of herpes simplex virus type 2 (HSV-2) acquisition on the plasma HIV RNA and CD4 cell levels among individuals with primary HIV infection using a retrospective cohort analysis. We studied 119 adult, antiretroviral-naive, recently HIV-infected men with a negative HSV-2-specific enzyme immunoassay (EIA) result at enrollment. HSV-2 acquisition was determined by seroconversion on HSV-2 EIA, confirmed by Western blot analysis. Ten men acquired HSV-2 infection a median of 1.3 years after HIV infection (HSV-2 incidence rate of 7.4 per 100 person-years of follow-up). The median time of follow-up after acquiring HSV-2 infection was 303 days. All men except 1 were asymptomatic during HSV-2 acquisition, and only 1 HSV-2 seroconverter, who was asymptomatic, had a transient increase in blood HIV load (0.5 log10 copies/mL over 11 days). The HSV-2 incidence rate was high in our cohort of recently HIV-infected individuals; however, HSV-2 acquisition did not significantly change the plasma HIV dynamics and CD4 cell levels.

DOI10.1097/QAI.0b013e318163bd87
PubMed URLhttp://www.ncbi.nlm.nih.gov/pubmed/18197122?dopt=Abstract
PMCPMC2630881
Alternate TitleJ. Acquir. Immune Defic. Syndr.
PubMed ID18197122