Integrating physical and genetic maps: from genomes to interaction networks.

TitleIntegrating physical and genetic maps: from genomes to interaction networks.
Publication TypeJournal Article
Year of Publication2007
AuthorsBeyer A, Bandyopadhyay S, Ideker T
JournalNat Rev Genet
Volume8
Issue9
Pagination699-710
Date Published2007 Sep
ISSN1471-0056
KeywordsGene Regulatory Networks, Genetic Techniques, Genome, Human, Humans, Models, Biological, Physical Chromosome Mapping, Signal Transduction
Abstract

Physical and genetic mapping data have become as important to network biology as they once were to the Human Genome Project. Integrating physical and genetic networks currently faces several challenges: increasing the coverage of each type of network; establishing methods to assemble individual interaction measurements into contiguous pathway models; and annotating these pathways with detailed functional information. A particular challenge involves reconciling the wide variety of interaction types that are currently available. For this purpose, recent studies have sought to classify genetic and physical interactions along several complementary dimensions, such as ordered versus unordered, alleviating versus aggravating, and first versus second degree.

DOI10.1038/nrg2144
PubMed URLhttp://www.ncbi.nlm.nih.gov/pubmed/17703239?dopt=Abstract
PMCPMC2811081
Alternate TitleNat. Rev. Genet.
PubMed ID17703239