Reconstruction of cellular signalling networks and analysis of their properties.
|Title||Reconstruction of cellular signalling networks and analysis of their properties.|
|Publication Type||Journal Article|
|Year of Publication||2005|
|Authors||Papin JA, Hunter T, Palsson BO, Subramaniam S|
|Journal||Nat Rev Mol Cell Biol|
|Date Published||2005 Feb|
|Keywords||Animals, Cell Physiological Phenomena, Computational Biology, Computer Simulation, Humans, Models, Biological, Models, Molecular, Models, Theoretical, Protein Interaction Mapping, Signal Transduction, Time Factors|
The study of cellular signalling over the past 20 years and the advent of high-throughput technologies are enabling the reconstruction of large-scale signalling networks. After careful reconstruction of signalling networks, their properties must be described within an integrative framework that accounts for the complexity of the cellular signalling network and that is amenable to quantitative modelling.
|Alternate Journal||Nat. Rev. Mol. Cell Biol.|