Reconstruction of cellular signalling networks and analysis of their properties.

TitleReconstruction of cellular signalling networks and analysis of their properties.
Publication TypeJournal Article
Year of Publication2005
AuthorsPapin JA, Hunter T, Palsson BO, Subramaniam S
JournalNat Rev Mol Cell Biol
Volume6
Issue2
Pagination99-111
Date Published2005 Feb
ISSN1471-0072
KeywordsAnimals, Cell Physiological Phenomena, Computational Biology, Computer Simulation, Humans, Models, Biological, Models, Molecular, Models, Theoretical, Protein Interaction Mapping, Signal Transduction, Time Factors
Abstract

The study of cellular signalling over the past 20 years and the advent of high-throughput technologies are enabling the reconstruction of large-scale signalling networks. After careful reconstruction of signalling networks, their properties must be described within an integrative framework that accounts for the complexity of the cellular signalling network and that is amenable to quantitative modelling.

DOI10.1038/nrm1570
PubMed URLhttp://www.ncbi.nlm.nih.gov/pubmed/15654321?dopt=Abstract
Alternate TitleNat. Rev. Mol. Cell Biol.
PubMed ID15654321