Flagellar biosynthesis in silico: building quantitative models of regulatory networks.

TitleFlagellar biosynthesis in silico: building quantitative models of regulatory networks.
Publication TypeJournal Article
Year of Publication2004
AuthorsHerrgård MJ, Palsson BØ
JournalCell
Volume117
Issue6
Pagination689-90
Date Published2004 Jun 11
ISSN0092-8674
KeywordsComputer Simulation, Escherichia coli, Escherichia coli Proteins, Flagella, Gene Expression Regulation, Bacterial, Genes, Regulator, Models, Biological
Abstract

In this issue of Cell, describe the construction of an in silico model for the regulatory network responsible for the control of flagellar biosynthesis in E. coli based on quantitative gene expression data. They show how the model can be used as a quantitative blueprint to design genetic modifications with predictable influence on the dynamics of the system. The work by provides a general approach for building detailed models of transcriptional regulatory networks.

DOI10.1016/j.cell.2004.05.020
PubMed URLhttp://www.ncbi.nlm.nih.gov/pubmed/15186769?dopt=Abstract
Alternate JournalCell
PubMed ID15186769