Reconstruction of microbial transcriptional regulatory networks.

TitleReconstruction of microbial transcriptional regulatory networks.
Publication TypeJournal Article
Year of Publication2004
AuthorsHerrgård MJ, Covert MW, Palsson BØ
JournalCurr Opin Biotechnol
Volume15
Issue1
Pagination70-7
Date Published2004 Feb
ISSN0958-1669
KeywordsBacteria, Bacterial Proteins, Databases, Protein, Evolution, Molecular, Gene Expression Profiling, Gene Expression Regulation, Bacterial, Genome, Bacterial, Models, Biological, Signal Transduction, Transcription, Genetic
Abstract

Although metabolic networks can be readily reconstructed through comparative genomics, the reconstruction of regulatory networks has been hindered by the relatively low level of evolutionary conservation of their molecular components. Recent developments in experimental techniques have allowed the generation of vast amounts of data related to regulatory networks. This data together with literature-derived knowledge has opened the way for genome-scale reconstruction of transcriptional regulatory networks. Large-scale regulatory network reconstructions can be converted to in silico models that allow systematic analysis of network behavior in response to changes in environmental conditions. These models can further be combined with genome-scale metabolic models to build integrated models of cellular function including both metabolism and its regulation.

DOI10.1016/j.copbio.2003.11.002
PubMed URLhttp://www.ncbi.nlm.nih.gov/pubmed/15102470?dopt=Abstract
Alternate TitleCurr. Opin. Biotechnol.
PubMed ID15102470